IFA38/YBR159W Summary Help

Standard Name IFA38 1
Systematic Name YBR159W
Feature Type ORF, Verified
Description Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides (2, 3)
Chromosomal Location
ChrII:558685 to 559728 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IFA38 GO evidence and references
  View Computational GO annotations for IFA38
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
180 total interaction(s) for 157 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 32
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 101
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Lethality: 3
  • Negative Genetic: 25
  • Positive Genetic: 7
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 347
Molecular Weight (Da) 38,708
Isoelectric Point (pI) 10.28
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:558685 to 559728 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1044 558685..559728 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000363
References cited on this page View Complete Literature Guide for IFA38
1) Gopalacharyulu PV, et al.  (2009) Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast. Mol Biosyst 5(3):276-87
2) Beaudoin F, et al.  (2002) A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. J Biol Chem 277(13):11481-8
3) Han G, et al.  (2002) The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase. J Biol Chem 277(38):35440-9