Standard Name	IES4 1
Systematic Name	YOR189W
Feature Type	ORF, Verified
Description	Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses (1, 2)
Name Description	Ino Eighty Subunit 1

Chromosomal Location	ChrXV:689624 to 689974 | ORF Map | GBrowse

	View Computational GO annotations for IES4
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	response to DNA damage stimulus (IGI, IMP)
Cellular Component
Manually curated	Ino80 complex (IDA)
High-throughput	nucleus (IDA)

Classical genetics
activation	cell cycle progression in S phase: arrested resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	auxotrophy bud morphology: abnormal competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to bleomycin: decreased resistance to fluconazole: increased resistance to hydroxyurea: decreased resistance to tunicamycin: decreased resistance to camptothecin: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	153 total interaction(s) for 114 unique genes/features.
Physical Interactions	Affinity Capture-MS: 32 Affinity Capture-RNA: 3 Biochemical Activity: 2
Genetic Interactions	Negative Genetic: 97 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 10 Synthetic Growth Defect: 3 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:689624 to 689974 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..351 689624..689974 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005715