IES2/YNL215W Summary Help

Standard Name IES2 1
Systematic Name YNL215W
Feature Type ORF, Verified
Description Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Ino Eighty Subunit 1
Chromosomal Location
ChrXIV:244468 to 245430 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IES2 GO evidence and references
  View Computational GO annotations for IES2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
304 total interaction(s) for 240 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 6

Genetic Interactions
  • Negative Genetic: 206
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 24
  • Synthetic Growth Defect: 29
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 320
Molecular Weight (Da) 36,154
Isoelectric Point (pI) 4.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:244468 to 245430 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..963 244468..245430 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005159
References cited on this page View Complete Literature Guide for IES2
1) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
2) Ishtar Snoek IS and Yde Steensma H  (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76