IES2/YNL215W Summary Help

Standard Name IES2 1
Systematic Name YNL215W
Feature Type ORF, Verified
Description Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Ino Eighty Subunit 1
Chromosomal Location
ChrXIV:244468 to 245430 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IES2 GO evidence and references
  View Computational GO annotations for IES2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 112 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
304 total interaction(s) for 240 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 26
  • Affinity Capture-RNA: 2
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 6

Genetic Interactions
  • Negative Genetic: 206
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 24
  • Synthetic Growth Defect: 29
  • Synthetic Lethality: 7

Resources
Expression Summary
histogram
Resources
Length (a.a.) 320
Molecular Weight (Da) 36,154
Isoelectric Point (pI) 4.43
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:244468 to 245430 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..963 244468..245430 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005159
References cited on this page View Complete Literature Guide for IES2
1) Shen X, et al.  (2003) Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55
2) Snoek IS and Steensma HY  (2006) Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. FEMS Yeast Res 6(3):393-403
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76