IDP2/YLR174W Summary

IDP2 BASIC INFORMATION

Standard Name	IDP2
Systematic Name	YLR174W
Feature Type	ORF, Verified
Description	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose (1, 2)
Name Description	Isocitrate Dehydrogenase, NADP-specific

GO Annotations	All IDP2 GO evidence and references
	View Computational GO annotations for IDP2
Molecular Function
Manually curated	isocitrate dehydrogenase (NADP+) activity (TAS)
Biological Process
Manually curated	glutamate biosynthetic process (TAS) isocitrate metabolic process (IGI, IMP)
Cellular Component
Manually curated	cytosol (IDA)

Pathways	superpathway of glutamate biosynthesis

Mutant Phenotype	All IDP2 Phenotype details and references
Classical genetics
null	isocitrate(3-) accumulation: increased
Large-scale survey
null	viable

Interactions	IDP2 All interactions details and references
	5 total interaction(s) for 4 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1
Genetic Interactions	Dosage Rescue: 2 Synthetic Growth Defect: 1 Synthetic Lethality: 1

Sequence Information

ChrXII:504593 to 505831 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1239	504593..505831	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004164

IDP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IDP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IDP2]

1)	Loftus TM, et al. (1994) Isolation, characterization, and disruption of the yeast gene encoding cytosolic NADP-specific isocitrate dehydrogenase. Biochemistry 33(32):9661-7
2)	Haselbeck RJ and McAlister-Henn L (1993) Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. J Biol Chem 268(16):12116-22

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