IDP1/YDL066W Summary

IDP1 BASIC INFORMATION

Standard Name	IDP1
Systematic Name	YDL066W
Feature Type	ORF, Verified
Description	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes (1, 2)
Name Description	Isocitrate Dehydrogenase, NADP-specific

GO Annotations	All IDP1 GO evidence and references
	View Computational GO annotations for IDP1
Molecular Function
Manually curated	isocitrate dehydrogenase (NADP+) activity (TAS)
Biological Process
Manually curated	glutamate biosynthetic process (IGI, IMP) isocitrate metabolic process (TAS)
Cellular Component
Manually curated	mitochondrial nucleoid (IDA) mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of glutamate biosynthesis

Mutant Phenotype	All IDP1 Phenotype details and references
Classical genetics
null	isocitrate(3-) accumulation: increased 2-oxoglutarate(2-) accumulation: decreased resistance to bortezomib: decreased
Large-scale survey
null	cell size: increased viable

Interactions	IDP1 All interactions details and references
	16 total interaction(s) for 15 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 1

Sequence Information

ChrIV:334835 to 336121 | |

Last Update

Coordinates: 2004-02-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1287	334835..336121	2004-02-11	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002224

IDP1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IDP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IDP1]

1)	Haselbeck RJ and McAlister-Henn L (1991) Isolation, nucleotide sequence, and disruption of the Saccharomyces cerevisiae gene encoding mitochondrial NADP(H)-specific isocitrate dehydrogenase. J Biol Chem 266(4):2339-45
2)	Haselbeck RJ and McAlister-Henn L (1993) Function and expression of yeast mitochondrial NAD- and NADP-specific isocitrate dehydrogenases. J Biol Chem 268(16):12116-22

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