IDH1/YNL037C Summary

IDH1 BASIC INFORMATION

Standard Name	IDH1
Systematic Name	YNL037C
Feature Type	ORF, Verified
Description	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle (1)
Name Description	Isocitrate DeHydrogenase

GO Annotations	All IDH1 GO evidence and references
	View Computational GO annotations for IDH1
Molecular Function
Manually curated	contributes_to isocitrate dehydrogenase (NAD+) activity (IDA)
Biological Process
Manually curated	glutamate biosynthetic process (TAS) isocitrate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial isocitrate dehydrogenase complex (NAD+) (IDA) mitochondrial matrix (IDA) mitochondrial nucleoid (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Mutant Phenotype	All IDH1 Phenotype details and references
Classical genetics
null	resistance to rapamycin: increased
reduction of function	mitochondrial genome maintenance: decreased utilization of carbon source: absent utilization of carbon source: decreased
unspecified	utilization of carbon source: absent
Large-scale survey
null	hyperosmotic stress resistance: decreased replicative lifespan: increased respiratory growth: decreased rate viable

Interactions	IDH1 All interactions details and references
	35 total interaction(s) for 24 unique genes/features.
Physical Interactions	Affinity Capture-MS: 15 Affinity Capture-Western: 1 Co-crystal Structure: 1 Co-purification: 1 PCA: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 5 Phenotypic Suppression: 3 Synthetic Growth Defect: 2 Synthetic Rescue: 1

Sequence Information

ChrXIV:559004 to 557922 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2010-01-05 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1083	559004..557922	2010-01-05	1997-01-28

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004982

IDH1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IDH1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IDH1]

1)	Cupp JR and McAlister-Henn L (1992) Cloning and characterization of the gene encoding the IDH1 subunit of NAD(+)-dependent isocitrate dehydrogenase from Saccharomyces cerevisiae. J Biol Chem 267(23):16417-23

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