Standard Name	IDH1
Systematic Name	YNL037C
Feature Type	ORF, Verified
Description	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle (1)
Name Description	Isocitrate DeHydrogenase

Chromosomal Location	ChrXIV:559002 to 557920 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for IDH1
Molecular Function
Manually curated	contributes_to isocitrate dehydrogenase (NAD+) activity (IDA)
Biological Process
Manually curated	glutamate biosynthetic process (TAS) isocitrate metabolic process (TAS) tricarboxylic acid cycle (TAS)
Cellular Component
Manually curated	mitochondrial isocitrate dehydrogenase complex (NAD+) (IDA) mitochondrial matrix (IDA) mitochondrial nucleoid (IDA)
High-throughput	mitochondrion (IDA)

Pathways	superpathway of TCA cycle and glyoxylate cycle TCA cycle, aerobic respiration

Classical genetics
null	replicative lifespan: increased resistance to sirolimus: increased utilization of carbon source: absent
reduction of function	mitochondrial genome maintenance: decreased utilization of carbon source: decreased utilization of carbon source: absent
unspecified	utilization of carbon source: absent
Large-scale survey
null	competitive fitness: decreased haploinsufficient hyperosmotic stress resistance: decreased replicative lifespan: increased respiratory growth: decreased rate starvation resistance: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	212 total interaction(s) for 136 unique genes/features.
Physical Interactions	Affinity Capture-MS: 22 Affinity Capture-RNA: 1 Affinity Capture-Western: 2 Co-crystal Structure: 2 Co-purification: 1 PCA: 1 Reconstituted Complex: 1 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 132 Phenotypic Enhancement: 5 Phenotypic Suppression: 4 Positive Genetic: 27 Synthetic Growth Defect: 6 Synthetic Lethality: 2 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:559002 to 557920 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1083 559002..557920 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004982