ICL1/YER065C Summary Help

Standard Name ICL1 1
Systematic Name YER065C
Feature Type ORF, Verified
Description Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose (1, 2)
Name Description IsoCitrate Lyase 1
Chromosomal Location
ChrV:286914 to 285241 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All ICL1 GO evidence and references
  View Computational GO annotations for ICL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
Resources
31 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 6
  • Positive Genetic: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 557
Molecular Weight (Da) 62,408
Isoelectric Point (pI) 6.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:286914 to 285241 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1674 286914..285241 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000867
References cited on this page View Complete Literature Guide for ICL1
1) Fernandez E, et al.  (1992) The ICL1 gene from Saccharomyces cerevisiae. Eur J Biochem 204(3):983-90
2) Luttik MA, et al.  (2000) The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism. J Bacteriol 182(24):7007-13