Standard Name	ICE2 1
Systematic Name	YIL090W
Feature Type	ORF, Verified
Description	Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells (1, 2, 3)
Name Description	Inheritance of Cortical ER 1

Chromosomal Location	ChrIX:193595 to 195070 | ORF Map | GBrowse

	View Computational GO annotations for ICE2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cellular zinc ion homeostasis (IMP) endoplasmic reticulum inheritance (IGI, IMP) protein targeting to nuclear inner membrane (IMP) septin ring assembly (IGI, IMP)
Cellular Component
Manually curated	cortical endoplasmic reticulum (IDA) integral to endoplasmic reticulum membrane (IDA) perinuclear endoplasmic reticulum (IDA)
High-throughput	endoplasmic reticulum (IDA) integral to membrane (ISM)

Classical genetics
null	chromosome/plasmid maintenance: abnormal endoplasmic reticulum morphology: abnormal metal resistance: decreased Trm1p-II-GFP distribution: abnormal
Large-scale survey
null	polyphosphate accumulation: abnormal competitive fitness: decreased endocytosis: decreased metal resistance: decreased resistance to benzo[a]pyrene: increased resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to cycloheximide: increased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to fenpropimorph: decreased resistance to fluconazole: decreased resistance to dimethyl sulfoxide: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased stress resistance: decreased transposable element transposition: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	473 total interaction(s) for 261 unique genes/features.
Genetic Interactions	Negative Genetic: 290 Phenotypic Enhancement: 10 Phenotypic Suppression: 16 Positive Genetic: 138 Synthetic Growth Defect: 15 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:193595 to 195070 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1476 193595..195070 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001352