Standard Name	IBA57 1
Systematic Name	YJR122W
Alias	CAF17
Feature Type	ORF, Verified
Description	Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system (1, 2)
Name Description	Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins 1

Chromosomal Location	ChrX:649776 to 651269 | ORF Map | GBrowse

	View Computational GO annotations for IBA57
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	iron-sulfur cluster assembly (IMP)
Cellular Component
Manually curated	mitochondrial matrix (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	auxotrophy mitochondrial genome maintenance: absent Aco1p activity: absent Bio2p activity: absent Lip5p activity: absent Lys4p modification: absent Aco1p modification: absent respiratory growth: decreased rate respiratory metabolism: absent
repressible	Aco1p activity: decreased
Large-scale survey
null	chronological lifespan: increased competitive fitness: decreased haploinsufficient heat sensitivity: increased mitochondrial genome maintenance: abnormal oxidative stress resistance: decreased resistance to sirolimus: decreased resistance to hydroxyurea: increased resistance to elesclomol-Cu: decreased resistance to sorbate: decreased resistance to pyrrolidine dithiocarbamate: decreased resistance to wortmannin: decreased resistance to propan-1-ol: decreased respiratory growth: absent respiratory growth: decreased rate starvation resistance: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	13 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2 Affinity Capture-Western: 4 PCA: 2 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 1 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:649776 to 651269 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1494 649776..651269 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003883