IBA57/YJR122W Summary Help

Standard Name IBA57 1
Systematic Name YJR122W
Alias CAF17
Feature Type ORF, Verified
Description Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system (1, 2)
Name Description Iron-sulfur cluster assembly factor for Biotin synthase and Aconitase-like mitochondrial proteins 1
Chromosomal Location
ChrX:649776 to 651269 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All IBA57 GO evidence and references
  View Computational GO annotations for IBA57
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
repressible
Large-scale survey
null
overexpression
Resources
14 total interaction(s) for 12 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 4
  • PCA: 2
  • Two-hybrid: 1

Genetic Interactions
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 497
Molecular Weight (Da) 57,054
Isoelectric Point (pI) 8.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:649776 to 651269 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1494 649776..651269 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003883
References cited on this page View Complete Literature Guide for IBA57
1) Gelling C, et al.  (2008) Mitochondrial Iba57p Is Required for Fe/S Cluster Formation on Aconitase and Activation of Radical SAM Enzymes. Mol Cell Biol 28(5):1851-1861
2) Clark LB, et al.  (2004) Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. J Biol Chem 279(14):13616-23