TID3/YIL144W Summary Help

TID3 BASIC INFORMATION

Standard Name TID3
Systematic Name YIL144W
Alias NDC80 , HEC1
Feature Type ORF, Verified
Description Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering (1, 2, 3, 4, 5, 6)
Name Description Two-hybrid Interaction with Dmc1p 7
GO Annotations All TID3 GO evidence and references
    View Computational GO annotations for TID3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All TID3 Phenotype details and references
Classical genetics
overexpression
Large-scale survey
null
overexpression
Interactions TID3 All interactions details and references
124 total interaction(s) for 66 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-Western: 22
  • Biochemical Activity: 2
  • Co-fractionation: 3
  • Co-localization: 1
  • Co-purification: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 53
Genetic Interactions
  • Dosage Rescue: 5
  • Synthetic Lethality: 6
  • Synthetic Rescue: 2
Sequence Information
ChrIX:78074 to 80149 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2076 78074..80149 1994-12-10 1994-12-10
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001406

TID3 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TID3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TID3]

1) Zheng L, et al.  (1999) Hec1p, an evolutionarily conserved coiled-coil protein, modulates chromosome segregation through interaction with SMC proteins. Mol Cell Biol 19(8):5417-28
2) Wigge PA and Kilmartin JV  (2001) The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J Cell Biol 152(2):349-60
3) Janke C, et al.  (2001) The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control. EMBO J 20(4):777-91
4) McCleland ML, et al.  (2003) The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity. Genes Dev 17(1):101-14
5) Westermann S, et al.  (2003) Architecture of the budding yeast kinetochore reveals a conserved molecular core. J Cell Biol 163(2):215-22
6) He X, et al.  (2001) Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell 106(2):195-206
7) Dresser ME, et al.  (1997) DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway. Genetics 147(2):533-44