HXT6/YDR343C Summary Help

Standard Name HXT6 1
Systematic Name YDR343C
Feature Type ORF, Verified
Description High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description HeXose Transporter 1
Chromosomal Location
ChrIV:1161320 to 1159608 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HXT6 GO evidence and references
  View Computational GO annotations for HXT6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
32 total interaction(s) for 30 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2
  • Co-fractionation: 2
  • Co-purification: 1
  • PCA: 2

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 6
  • Positive Genetic: 3

Expression Summary
Length (a.a.) 570
Molecular Weight (Da) 62,705
Isoelectric Point (pI) 7.7
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIV:1161320 to 1159608 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1713 1161320..1159608 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000002751
References cited on this page View Complete Literature Guide for HXT6
1) Reifenberger E, et al.  (1995) Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux. Mol Microbiol 16(1):157-67
2) Ozcan S and Johnston M  (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69
3) Reifenberger E, et al.  (1997) Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression. Eur J Biochem 245(2):324-33
4) Liang H and Gaber RF  (1996) A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6. Mol Biol Cell 7(12):1953-66
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61