HTL1/YCR020W-B Summary Help

Standard Name HTL1 1
Systematic Name YCR020W-B
Feature Type ORF, Verified
Description Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance (1, 2, 3, 4, 5, 6)
Name Description High-Temperature Lethal 1, 2
Chromosomal Location
ChrIII:155320 to 155556 | ORF Map | GBrowse
Gene Ontology Annotations All HTL1 GO evidence and references
  View Computational GO annotations for HTL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
81 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 46
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 4
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 78
Molecular Weight (Da) 9,179
Isoelectric Point (pI) 9.33
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIII:155320 to 155556 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1999-07-17
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..237 155320..155556 2011-02-03 1999-07-17
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006439
References cited on this page View Complete Literature Guide for HTL1
1) Lu YM, et al.  (2003) Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex. Mol Genet Genomics 269(3):321-30
2) Lanzuolo C, et al.  (2001) The HTL1 gene (YCR020W-b) of Saccharomyces cerevisiae is necessary for growth at 37 degrees C, and for the conservation of chromosome stability and fertility. Yeast 18(14):1317-30
3) Romeo MJ, et al.  (2002) HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae. Mol Cell Biol 22(23):8165-74
4) Baetz KK, et al.  (2004) The ctf13-30/CTF13 genomic haploinsufficiency modifier screen identifies the yeast chromatin remodeling complex RSC, which is required for the establishment of sister chromatid cohesion. Mol Cell Biol 24(3):1232-44
5) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
6) Carey M, et al.  (2006) RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation. Mol Cell 24(3):481-7