Standard Name	HTD2
Systematic Name	YHR067W
Alias	RMD12
Feature Type	ORF, Verified
Description	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology (1, 2, 3)
Name Description	Hydroxyacyl-Thioester Dehydratase 1, 3

Chromosomal Location	ChrVIII:230970 to 231812 | ORF Map | GBrowse

	View Computational GO annotations for HTD2
Molecular Function
Manually curated	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity (IDA)
Biological Process
Manually curated	fatty acid biosynthetic process (IGI, ISS)
Cellular Component
Manually curated	mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	mature RPM1 RNA accumulation: decreased Ptr2p-GFP distribution: abnormal Kgd2p modification: absent respiratory growth: absent
Large-scale survey
null	cell cycle progression in G1 phase: increased duration glycogen accumulation: decreased competitive fitness: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased nutrient utilization: decreased resistance to ethanol: decreased resistance to sodium arsenite: decreased resistance to quinine: decreased resistance to pentachlorophenol: decreased resistance to sorbate: decreased resistance to acetic acid: decreased respiratory growth: absent respiratory growth: decreased respiratory growth: decreased rate sporulation: absent stress resistance: increased toxin resistance: increased utilization of carbon source: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	175 total interaction(s) for 136 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 1 Protein-peptide: 1 Reconstituted Complex: 2 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 137 Positive Genetic: 21 Synthetic Growth Defect: 8 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:230970 to 231812 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..843 230970..231812 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001109