HTD2/YHR067W Summary Help

Standard Name HTD2 1
Systematic Name YHR067W
Alias RMD12
Feature Type ORF, Verified
Description Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology (1, 2, 3)
Name Description Hydroxyacyl-Thioester Dehydratase 1, 2
Chromosomal Location
ChrVIII:230970 to 231812 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HTD2 GO evidence and references
  View Computational GO annotations for HTD2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
176 total interaction(s) for 136 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Protein-peptide: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 137
  • Positive Genetic: 21
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 280
Molecular Weight (Da) 33,055
Isoelectric Point (pI) 9
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:230970 to 231812 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..843 230970..231812 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001109
References cited on this page View Complete Literature Guide for HTD2
1) Kastaniotis AJ, et al.  (2004) Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology. Mol Microbiol 53(5):1407-21
2) Enyenihi AH and Saunders WS  (2003) Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163(1):47-54
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91