HSV2/YGR223C Summary Help

Standard Name HSV2 1
Systematic Name YGR223C
Feature Type ORF, Verified
Description Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization (1, 2, 3)
Name Description Homologous with SVP1 1
Chromosomal Location
ChrVII:942215 to 940869 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HSV2 GO evidence and references
  View Computational GO annotations for HSV2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
46 total interaction(s) for 44 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Biochemical Activity: 3
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 6

Genetic Interactions
  • Negative Genetic: 12
  • Positive Genetic: 11
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 448
Molecular Weight (Da) 51,235
Isoelectric Point (pI) 9.76
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:942215 to 940869 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1347 942215..940869 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003455
References cited on this page View Complete Literature Guide for HSV2
1) Dove SK, et al.  (2004) Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J 23(9):1922-33
2) Krick R, et al.  (2008) Dissecting the localization and function of Atg18, Atg21 and Ygr223c. Autophagy 4(7):896-910
3) Baskaran S, et al.  (2012) Two-site recognition of phosphatidylinositol 3-phosphate by PROPPINs in autophagy. Mol Cell 47(3):339-48