HST4/YDR191W Summary Help

Standard Name HST4 1
Systematic Name YDR191W
Feature Type ORF, Verified
Description Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism (1, 2, 3)
Name Description Homolog of SIR Two (SIR2) 1, 4
Chromosomal Location
ChrIV:842337 to 843449 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HST4 GO evidence and references
  View Computational GO annotations for HST4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
97 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 34
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 4
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 15
  • Synthetic Rescue: 16

Resources
Expression Summary
histogram
Resources
Length (a.a.) 370
Molecular Weight (Da) 41,765
Isoelectric Point (pI) 9.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:842337 to 843449 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1113 842337..843449 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002599
References cited on this page View Complete Literature Guide for HST4
1) Brachmann CB, et al.  (1995) The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9(23):2888-902
2) Smith JS, et al.  (2000) A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A 97(12):6658-63
3) Starai VJ, et al.  (2003) Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics 163(2):545-55
4) Derbyshire MK, et al.  (1996) HST1, a new member of the SIR2 family of genes. Yeast 12(7):631-40