HSP60/YLR259C Summary Help

HSP60 BASIC INFORMATION

Standard Name HSP60 1
Systematic Name YLR259C
Alias CPN60 2 , MIF4 3 , MNA2 4 , 5
Feature Type ORF, Verified
Description Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated (1, 3, 6, 7, 8, 9)
Name Description Heat Shock Protein 1, 10
GO Annotations All HSP60 GO evidence and references
    View Computational GO annotations for HSP60
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All HSP60 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions HSP60 All interactions details and references
54 total interaction(s) for 48 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 42
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 3
  • Co-purification: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 1
Genetic Interactions
  • Synthetic Lethality: 3
Sequence Information
ChrXII:665004 to 663286 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1719 665004..663286 2004-02-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004249

HSP60 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HSP60

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSP60]

1) Reading DS, et al.  (1989) Characterization of the yeast HSP60 gene coding for a mitochondrial assembly factor. Nature 337(6208):655-9
2) Rospert S, et al.  (1993) Identification and functional analysis of chaperonin 10, the groES homolog from yeast mitochondria. Proc Natl Acad Sci U S A 90(23):10967-71
3) Cheng MY, et al.  (1989) Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337(6208):620-5
4) Mueller DM, et al.  (1987) Temperature sensitive pet mutants in yeast Saccharomyces cerevisiae that lose mitochondrial RNA. Curr Genet 11(5):359-67
5) Sanyal A, et al.  (1995) Heat shock protein HSP60 can alleviate the phenotype of mitochondrial RNA-deficient temperature-sensitive mna2 pet mutants. Mol Gen Genet 246(1):56-64
6) Cheng MY, et al.  (1990) The mitochondrial chaperonin hsp60 is required for its own assembly. Nature 348(6300):455-8
7) Koll H, et al.  (1992) Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell 68(6):1163-75
8) Kaufman BA, et al.  (2003) A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae. J Cell Biol 163(3):457-61
9) Reinders J, et al.  (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
10) Johnson RB, et al.  (1989) Cloning and characterization of the yeast chaperonin HSP60 gene. Gene 84(2):295-302