HSP12/YFL014W Summary 
| Standard Name | HSP12 |
|---|---|
| Systematic Name | YFL014W |
| Alias | GLP1 , HOR5 1 |
| Feature Type | ORF, Verified |
| Description | Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) |
| Name Description | Heat Shock Protein 5 |
| Chromosomal Location | |
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Gene Ontology Annotations All HSP12 GO evidence and references
| View Computational GO annotations for HSP12 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All HSP12 Phenotype evidence and references
interactions All HSP12 Interaction evidence and references
| 29 total interaction(s) for 28 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All HSP12 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000001880 |
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References cited on this page View Complete Literature Guide for HSP12
| 1) | Hirayama T, et al. (1995) Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol Gen Genet 249(2):127-38 |
| 2) | Stone RL, et al. (1990) Cloning, sequencing and chromosomal assignment of a gene from Saccharomyces cerevisiae which is negatively regulated by glucose and positively by lipids. Gene 96(2):171-6 |
| 3) | Siderius M, et al. (1997) High-osmolarity signalling in Saccharomyces cerevisiae is modulated in a carbon-source-dependent fashion. Microbiology 143 ( Pt 10):3241-50 |
| 4) | Rep M, et al. (1999) Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Mol Cell Biol 19(8):5474-85 |
| 5) | Praekelt UM and Meacock PA (1990) HSP12, a new small heat shock gene of Saccharomyces cerevisiae: analysis of structure, regulation and function. Mol Gen Genet 223(1):97-106 |
| 6) | Garay-Arroyo A, et al. (2000) Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit. J Biol Chem 275(8):5668-74 |
| 7) | Sales K, et al. (2000) The LEA-like protein HSP 12 in Saccharomyces cerevisiae has a plasma membrane location and protects membranes against desiccation and ethanol-induced stress. Biochim Biophys Acta 1463(2):267-78 |
| 8) | Welker S, et al. (2010) Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function. Mol Cell 39(4):507-520 |
| 9) | Herbert AP, et al. (2012) NMR structure of hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast. PLoS One 7(7):e41975 |
| 10) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
