HSL7/YBR133C Summary Help

Standard Name HSL7 1
Systematic Name YBR133C
Feature Type ORF, Verified
Description Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress (2, 3, 4, 5, 6, 7, 8)
Name Description Histone Synthetic Lethal 1
Chromosomal Location
ChrII:504287 to 501804 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HSL7 GO evidence and references
  View Computational GO annotations for HSL7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Classical genetics
Large-scale survey
56 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 12
  • Biochemical Activity: 4
  • Co-localization: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 10

Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 4
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 6
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 827
Molecular Weight (Da) 95,152
Isoelectric Point (pI) 6.32
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrII:504287 to 501804 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2484 504287..501804 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000337
References cited on this page View Complete Literature Guide for HSL7
1) Ma XJ, et al.  (1996) A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev 10(11):1327-40
2) McMillan JN, et al.  (1999) The morphogenesis checkpoint in Saccharomyces cerevisiae: cell cycle control of Swe1p degradation by Hsl1p and Hsl7p. Mol Cell Biol 19(10):6929-39
3) Shulewitz MJ, et al.  (1999) Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7123-37
4) Longtine MS, et al.  (2000) Septin-dependent assembly of a cell cycle-regulatory module in Saccharomyces cerevisiae. Mol Cell Biol 20(11):4049-61
5) Lee JH, et al.  (2000) Hsl7p, the yeast homologue of human JBP1, is a protein methyltransferase. Biochem Biophys Res Commun 274(1):105-11
6) Cid VJ, et al.  (2001) Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle. Mol Biol Cell 12(6):1645-69
7) Sakchaisri K, et al.  (2004) Coupling morphogenesis to mitotic entry. Proc Natl Acad Sci U S A 101(12):4124-9
8) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76