HSH49/YOR319W Summary Help

Standard Name HSH49 1
Systematic Name YOR319W
Feature Type ORF, Verified
Description U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) (1, 2, 3, 4)
Name Description Human Sap Homolog 1
Chromosomal Location
ChrXV:912822 to 913463 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HSH49 GO evidence and references
  View Computational GO annotations for HSH49
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
reduction of function
repressible
Resources
54 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 35
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 15

Resources
Expression Summary
histogram
Resources
Length (a.a.) 213
Molecular Weight (Da) 24,503
Isoelectric Point (pI) 9.95
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:912822 to 913463 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..642 912822..913463 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005846
References cited on this page View Complete Literature Guide for HSH49
1) Wells SE, et al.  (1996) CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145. Genes Dev 10(2):220-32
2) Pauling MH, et al.  (2000) Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Mol Cell Biol 20(6):2176-85
3) Igel H, et al.  (1998) Conservation of structure and subunit interactions in yeast homologues of splicing factor 3b (SF3b) subunits. RNA 4(1):1-10
4) Stevens SW, et al.  (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44