HSE1/YHL002W Summary

HSE1 BASIC INFORMATION

Standard Name	HSE1 1
Systematic Name	YHL002W
Feature Type	ORF, Verified
Description	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes (1, 2)
Name Description	Has Symptoms of class E mutants; resembles Hbp, Stam and East 1

GO Annotations	All HSE1 GO evidence and references
	View Computational GO annotations for HSE1
Molecular Function
Manually curated	protein binding (IDA)
Biological Process
Manually curated	late endosome to vacuole transport (IMP) protein targeting to vacuole (IMP, IPI)
Cellular Component
Manually curated	endosome (IDA) ESCRT-0 complex (IPI)

Mutant Phenotype	All HSE1 Phenotype details and references
Classical genetics
overexpression	budding: abnormal cellular morphology: abnormal
Large-scale survey
null	chitin deposition: decreased replicative lifespan: increased resistance to Calcofluor White: decreased viable
overexpression	vegetative growth: decreased

Interactions	HSE1 All interactions details and references
	77 total interaction(s) for 50 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-Western: 10 Co-crystal Structure: 1 PCA: 2 Reconstituted Complex: 3 Two-hybrid: 49
Genetic Interactions	Synthetic Lethality: 3 Synthetic Rescue: 1

Sequence Information

ChrVIII:102607 to 103965 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1359	102607..103965	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000994

HSE1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HSE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HSE1]

1)	Bilodeau PS, et al. (2002) The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol 4(7):534-9
2)	Bilodeau PS, et al. (2003) Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome. J Cell Biol 163(2):237-43

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