Standard Name	HRT3 1
Systematic Name	YLR097C
Feature Type	ORF, Verified
Description	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies (1, 2, 3, 4, 5, 6, 7)
Name Description	High level expression Reduces Ty3 transposition 1

Chromosomal Location	ChrXII:337265 to 336231 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for HRT3
Molecular Function
Manually curated	protein binding, bridging (ISA) contributes_to ubiquitin-protein ligase activity (ISA)
Biological Process
Manually curated	cellular response to methylmercury (IMP) SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IGI, ISA)
Cellular Component
Manually curated	SCF ubiquitin ligase complex (IDA, IPI)

Classical genetics
overexpression	budding: abnormal cellular morphology: abnormal resistance to methylmercury chloride: normal resistance to methylmercury chloride: increased resistance to MG132 and methylmercury chloride: normal
Large-scale survey
null	chronological lifespan: decreased competitive fitness: decreased viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	35 total interaction(s) for 22 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 2 Affinity Capture-Western: 2 Reconstituted Complex: 4 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 3 Negative Genetic: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:337265 to 336231 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1035 337265..336231 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004087