Standard Name	HRP1
Systematic Name	YOL123W
Alias	NAB4 , NAB5
Feature Type	ORF, Verified
Description	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences (1, 2, 3, 4)
Name Description	Heterogenous nuclear RibonucleoProtein 1

Chromosomal Location	ChrXV:87844 to 89448 | ORF Map | GBrowse

	View Computational GO annotations for HRP1
Molecular Function
Manually curated	mRNA binding (IDA) RNA binding (IDA)
Biological Process
Manually curated	mRNA cleavage (IDA) mRNA polyadenylation (IDA, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) cytoplasmic stress granule (IDA) mRNA cleavage factor complex (IPI) nucleus (IDA)
High-throughput	nucleus (IDA)

Classical genetics
reduction of function	heat sensitivity: increased inviable Hrp1p distribution: abnormal vegetative growth: decreased rate
Large-scale survey
conditional	colony sectoring: increased
null	haploproficient inviable starvation resistance: decreased
overexpression	inviable
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	87 total interaction(s) for 58 unique genes/features.
Physical Interactions	Affinity Capture-MS: 35 Affinity Capture-RNA: 3 Affinity Capture-Western: 15 Biochemical Activity: 7 Co-purification: 1 Reconstituted Complex: 7 Two-hybrid: 7
Genetic Interactions	Dosage Growth Defect: 2 Dosage Rescue: 1 Negative Genetic: 3 Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXV:87844 to 89448 | ORF Map | GBrowse
Last Update	Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1605 87844..89448 2006-01-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000005483