HRP1/YOL123W Summary Help

HRP1 BASIC INFORMATION

Standard Name HRP1
Systematic Name YOL123W
Alias NAB4 , NAB5
Feature Type ORF, Verified
Description Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences (1, 2, 3, 4)
Name Description Heterogenous nuclear RibonucleoProtein 1
GO Annotations All HRP1 GO evidence and references
    View Computational GO annotations for HRP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All HRP1 Phenotype details and references
Classical genetics
reduction of function
Large-scale survey
null
overexpression
Interactions HRP1 All interactions details and references
59 total interaction(s) for 34 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 8
  • Biochemical Activity: 8
  • Co-localization: 2
  • Co-purification: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 7
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1
Sequence Information
ChrXV:87844 to 89448 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1605 87844..89448 2006-01-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000005483

HRP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HRP1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HRP1]

1) Henry M, et al.  (1996) Potential RNA binding proteins in Saccharomyces cerevisiae identified as suppressors of temperature-sensitive mutations in NPL3. Genetics 142(1):103-15
2) Chen S and Hyman LE  (1998) A specific RNA-protein interaction at yeast polyadenylation efficiency elements. Nucleic Acids Res 26(21):4965-74
3) Kessler MM, et al.  (1997) Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast. Genes Dev 11(19):2545-56
4) Valentini SR, et al.  (1999) Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. RNA 5(2):272-80