HRD3/YLR207W Summary Help

Standard Name HRD3 1
Systematic Name YLR207W
Feature Type ORF, Verified
Description ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events (2)
Name Description HMG-coA Reductase Degradation 1
Chromosomal Location
ChrXII:556788 to 559289 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HRD3 GO evidence and references
  View Computational GO annotations for HRD3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
167 total interaction(s) for 70 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-Western: 30
  • Co-fractionation: 1
  • PCA: 4
  • Reconstituted Complex: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 23
  • Phenotypic Enhancement: 29
  • Phenotypic Suppression: 22
  • Positive Genetic: 39
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 833
Molecular Weight (Da) 95,480
Isoelectric Point (pI) 6.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:556788 to 559289 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2502 556788..559289 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004197
References cited on this page View Complete Literature Guide for HRD3
1) Hampton RY, et al.  (1996) Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol Biol Cell 7(12):2029-44
2) Gardner RG, et al.  (2000) Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. J Cell Biol 151(1):69-82