HPR1/YDR138W Summary Help

HPR1 BASIC INFORMATION

Standard Name HPR1
Systematic Name YDR138W
Alias TRF1 1
Feature Type ORF, Verified
Description Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p (2, 3, 4, 5, 6, 7, 8, 9)
Name Description HyPerRecombination 3
GO Annotations All HPR1 GO evidence and references
    View Computational GO annotations for HPR1
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Mutant Phenotype All HPR1 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions HPR1 All interactions details and references
219 total interaction(s) for 116 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 64
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 30
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 5
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 9
  • Phenotypic Enhancement: 23
  • Phenotypic Suppression: 19
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 29
  • Synthetic Rescue: 16

Sequence Information
ChrIV:730576 to 732834 | ORF Map | GBrowse
Gbrowse
Genetic position: 82 cM
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2259 730576..732834 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002545

HPR1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HPR1]

1) Sadoff BU, et al.  (1995) Isolation of mutants of Saccharomyces cerevisiae requiring DNA topoisomerase I. Genetics 141(2):465-79
2) Chang M, et al.  (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67
3) Aguilera A and Klein HL  (1990) HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene. Mol Cell Biol 10(4):1439-51
4) Chavez S, et al.  (2000) A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae. EMBO J 19(21):5824-34
5) Chavez S and Aguilera A  (1997) The yeast HPR1 gene has a functional role in transcriptional elongation that uncovers a novel source of genome instability. Genes Dev 11(24):3459-70
6) Chavez S, et al.  (2001) Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae. Mol Cell Biol 21(20):7054-64
7) Merker RJ and Klein HL  (2002) hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol 22(2):421-9
8) Jimeno S, et al.  (2002) The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability. EMBO J 21(13):3526-35
9) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63