HPM1/YIL110W Summary Help

Standard Name HPM1 1
Systematic Name YIL110W
Alias MNI1 2
Feature Type ORF, Verified
Description AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance (1, 3, 4, 5)
Name Description Histidine Protein Methyltransferase 1
Chromosomal Location
ChrIX:156045 to 157178 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HPM1 GO evidence and references
  View Computational GO annotations for HPM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 49 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
27 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1

Genetic Interactions
  • Negative Genetic: 15
  • Positive Genetic: 3
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 377
Molecular Weight (Da) 42,514
Isoelectric Point (pI) 4.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:156045 to 157178 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1134 156045..157178 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001372
References cited on this page View Complete Literature Guide for HPM1
1) Webb KJ, et al.  (2010) A Novel 3-Methylhistidine Modification of Yeast Ribosomal Protein Rpl3 Is Dependent upon the YIL110W Methyltransferase. J Biol Chem 285(48):37598-606
2) Bengtsson O, et al.  (2008) Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Yeast 25(11):835-47
3) Bonangelino CJ, et al.  (2002) Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2486-501
4) Katz JE, et al.  (2003) Automated identification of putative methyltransferases from genomic open reading frames. Mol Cell Proteomics 2(8):525-40
5) Lesage G, et al.  (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49