HPA3/YEL066W Summary Help

Standard Name HPA3 1
Systematic Name YEL066W
Feature Type ORF, Verified
Description D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates; experiments in the W303 strain indicate that translation may begin at the Met codon currently annotated as Met-19 (1, 2, 3, 4)
Name Description Histone and other Protein Acetyltransferase 1
Chromosomal Location
ChrV:26667 to 27206 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HPA3 GO evidence and references
  View Computational GO annotations for HPA3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
Resources
18 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 1
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 179
Molecular Weight (Da) 20,698
Isoelectric Point (pI) 7.88
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:26667 to 27206 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..540 26667..27206 1996-07-31 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000792
References cited on this page View Complete Literature Guide for HPA3
1) Angus-Hill ML, et al.  (1999) Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J Mol Biol 294(5):1311-25
2) Yow GY, et al.  (2004) D-amino acid N-acetyltransferase of Saccharomyces cerevisiae: a close homologue of histone acetyltransferase Hpa2p acting exclusively on free D-amino acids. Arch Microbiol 182(5):396-403
3) Yow GY, et al.  (2006) Physiological role of D: -amino acid-N-acetyltransferase of Saccharomyces cerevisiae: detoxification of D: -amino acids. Arch Microbiol 185(1):39-46
4) Sampath V, et al.  (2013) Biochemical Characterization of Hpa2 and Hpa3, Two Small Closely Related Acetyltransferases from Saccharomyces cerevisiae. J Biol Chem 288(30):21506-13