HOT13/YKL084W Summary Help

Standard Name HOT13 1
Systematic Name YKL084W
Feature Type ORF, Verified
Description Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc (1, 2)
Name Description Helper Of Tim 1
Chromosomal Location
ChrXI:280509 to 280859 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HOT13 GO evidence and references
  View Computational GO annotations for HOT13
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Large-scale survey
null
overexpression
Resources
4 total interaction(s) for 3 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Reconstituted Complex: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 116
Molecular Weight (Da) 13,641
Isoelectric Point (pI) 6.67
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:280509 to 280859 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..351 280509..280859 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001567
References cited on this page View Complete Literature Guide for HOT13
1) Curran SP, et al.  (2004) The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway. J Biol Chem 279(42):43744-51
2) Mesecke N, et al.  (2008) The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40. EMBO Rep 9(11):1107-13