Standard Name	HOT1 1
Systematic Name	YMR172W
Feature Type	ORF, Verified
Description	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p (1, 2, 3)
Name Description	High-Osmolarity-induced Transcription 1

Chromosomal Location	ChrXIII:605981 to 608140 | ORF Map | GBrowse

	View Computational GO annotations for HOT1
Molecular Function
Manually curated	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly (IDA, IMP) sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA)
Biological Process
Manually curated	cellular hyperosmotic salinity response (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress (IGI, IMP) RNA polymerase II transcriptional preinitiation complex assembly (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Large-scale survey
null	N-acetyl ornithine accumulation: decreased competitive fitness: decreased sporulation: normal vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	46 total interaction(s) for 30 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-RNA: 1 Biochemical Activity: 1 Co-localization: 1 Two-hybrid: 8
Genetic Interactions	Negative Genetic: 12 Synthetic Growth Defect: 1 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIII:605981 to 608140 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2160 605981..608140 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004783