HOS3/YPL116W Summary Help

Standard Name HOS3
Systematic Name YPL116W
Feature Type ORF, Verified
Description Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats (1, 2, 3 and see Summary Paragraph)
Name Description Hda One Similar 1
Chromosomal Location
ChrXVI:329606 to 331699 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HOS3 GO evidence and references
  View Computational GO annotations for HOS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant phenotypes All HOS3 Phenotype evidence and references
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
interactions All HOS3 Interaction evidence and references
60 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • PCA: 2
  • Protein-RNA: 1
  • Reconstituted Complex: 1
Genetic Interactions
  • Dosage Lethality: 8
  • Negative Genetic: 9
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 2
  • Synthetic Rescue: 6
Resources
Expression Summary
histogram
Resources
Protein Information All HOS3 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:329606 to 331699 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..2094 329606..331699 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006037
SUMMARY PARAGRAPH for HOS3

HOS3 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 4 and 5. Four other histone deactylases, Rpd3p, Hda1p, Hos1p, and Hos2p, have been identified in yeast; all share sequence similarity (1). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (1, 5).

Last updated: 2000-01-10

References cited on this page View Complete Literature Guide for HOS3
1) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
2) Carmen AA, et al.  (1999) Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. Proc Natl Acad Sci U S A 96(22):12356-61
3) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
4) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
5) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9