HOS2/YGL194C Summary Help

HOS2 BASIC INFORMATION

Standard Name HOS2
Systematic Name YGL194C
Alias RTL1
Feature Type ORF, Verified
Description Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity (1, 2, 3 and see Summary Paragraph)
Name Description Hda One Similar 4
GO Annotations All HOS2 GO evidence and references
    View Computational GO annotations for HOS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All HOS2 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions HOS2 All interactions details and references
230 total interaction(s) for 145 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
Genetic Interactions
  • Dosage Rescue: 2
  • Phenotypic Enhancement: 98
  • Phenotypic Suppression: 31
  • Synthetic Growth Defect: 37
  • Synthetic Lethality: 21
  • Synthetic Rescue: 4
Sequence Information
ChrVII:141732 to 140374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1359 141732..140374 2004-07-20 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003162

HOS2 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HOS2

SUMMARY PARAGRAPH for HOS2

HOS2 encodes a histone deacetylase (4). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 5 and 6. A homozygous null hos2 mutant shows reduced sporulation (7). Four other histone deactylases, Rpd3p, Hda1p, Hos1p, and Hos3p, have been identified in yeast; all share sequence similarity (4). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (4, 6).

Last updated: 2000-01-10

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOS2]

1) Pijnappel WW, et al.  (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004
2) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
3) Wang A, et al.  (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4
4) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
5) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
6) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9
7) Bilsland E, et al.  (1998) Genomic disruption of six budding yeast genes gives one drastic example of phenotype strain-dependence. Yeast 14(7):655-64