HOS2/YGL194C Summary Help

Standard Name HOS2 1
Systematic Name YGL194C
Alias RTL1
Feature Type ORF, Verified
Description Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS (2, 3, 4, 5 and see Summary Paragraph)
Name Description Hda One Similar 1
Chromosomal Location
ChrVII:141726 to 140368 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HOS2 GO evidence and references
  View Computational GO annotations for HOS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Classical genetics
reduction of function
Large-scale survey
410 total interaction(s) for 238 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 13
  • Dosage Rescue: 2
  • Negative Genetic: 217
  • Phenotypic Enhancement: 8
  • Phenotypic Suppression: 9
  • Positive Genetic: 53
  • Synthetic Growth Defect: 52
  • Synthetic Lethality: 10
  • Synthetic Rescue: 8

Expression Summary
Length (a.a.) 452
Molecular Weight (Da) 51,454
Isoelectric Point (pI) 4.88
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:141726 to 140368 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1359 141726..140368 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003162

HOS2 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 6 and 7. A homozygous null hos2 mutant shows reduced sporulation (8). Four other histone deactylases, Rpd3p, Hda1p, Hos1p, and Hos3p, have been identified in yeast; all share sequence similarity (1). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (1, 7).

Last updated: 2000-01-10 Contact SGD

References cited on this page View Complete Literature Guide for HOS2
1) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
2) Pijnappel WW, et al.  (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004
3) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
4) Wang A, et al.  (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
7) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9
8) Bilsland E, et al.  (1998) Genomic disruption of six budding yeast genes gives one drastic example of phenotype strain-dependence. Yeast 14(7):655-64