HOS2/YGL194C Summary 
| Standard Name | HOS2 |
|---|---|
| Systematic Name | YGL194C |
| Alias | RTL1 |
| Feature Type | ORF, Verified |
| Description | Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS (1, 2, 3, 4 and see Summary Paragraph) |
| Name Description | Hda One Similar 5 |
| Chromosomal Location | |
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| Note: this feature is encoded on the Crick strand. | |
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Gene Ontology Annotations All HOS2 GO evidence and references
| View Computational GO annotations for HOS2 | |
| Molecular Function | |
| Manually curated | |
| Biological Process | |
| Manually curated | |
| Cellular Component | |
| Manually curated | |
| High-throughput |
Mutant phenotypes All HOS2 Phenotype evidence and references
interactions All HOS2 Interaction evidence and references
| 406 total interaction(s) for 239 unique genes/features. | |
| Physical Interactions |
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| Genetic Interactions |
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| Resources |
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Expression Summary
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| Resources |
Protein Information All HOS2 Protein evidence and references
| Localization | |
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| Phosphorylation | PhosphoGRID | PhosphoPep Database |
| Structure | |
| Homologs |
sequence information
| Note: this feature is encoded on the Crick strand. | |||||||||||||
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| Last Update | Coordinates: 2011-02-03 | Sequence: 1996-07-31 | ||||||||||||
| Subfeature details |
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Analyze Sequence
| S288C only | |
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| S288C vs. other species | |
| S288C vs. other strains |
Resources
| External Links | All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB |
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| Primary SGDID | S000003162 |
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SUMMARY PARAGRAPH for HOS2
HOS2 encodes a histone deacetylase (5). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 6 and 7. A homozygous null hos2 mutant shows reduced sporulation (8). Four other histone deactylases, Rpd3p, Hda1p, Hos1p, and Hos3p, have been identified in yeast; all share sequence similarity (5). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (5, 7).
Last updated: 2000-01-10 
References cited on this page View Complete Literature Guide for HOS2
| 1) | Pijnappel WW, et al. (2001) The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev 15(22):2991-3004 |
| 2) | Robyr D, et al. (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46 |
| 3) | Wang A, et al. (2002) Requirement of Hos2 histone deacetylase for gene activity in yeast. Science 298(5597):1412-4 |
| 4) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 5) | Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 |
| 6) | Mizzen C, et al. (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81 |
| 7) | Suka N, et al. (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9 |
| 8) | Bilsland E, et al. (1998) Genomic disruption of six budding yeast genes gives one drastic example of phenotype strain-dependence. Yeast 14(7):655-64 |
