HOS1/YPR068C Summary Help

Standard Name HOS1 1
Systematic Name YPR068C
Alias CST3 2
Feature Type ORF, Verified
Description Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex (1, 3, 4, 5, 6 and see Summary Paragraph)
Name Description Hda One Similar 1
Chromosomal Location
ChrXVI:684353 to 682941 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HOS1 GO evidence and references
  View Computational GO annotations for HOS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
84 total interaction(s) for 73 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Lethality: 26
  • Negative Genetic: 27
  • Phenotypic Enhancement: 2
  • Positive Genetic: 4
  • Synthetic Growth Defect: 6
  • Synthetic Rescue: 3

Expression Summary
Length (a.a.) 470
Molecular Weight (Da) 54,763
Isoelectric Point (pI) 4.98
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrXVI:684353 to 682941 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1413 684353..682941 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006272

HOS1 encodes a histone deacetylase (1). Covalent modifications of histones, including acetylation and deacetylation, are implicated in transcriptional regulation in yeast and other eukaryotes, and have been reviewed in 7 and 8. Four other histone deactylases, Rpd3p, Hda1p, Hos2p, and Hos3p, have been identified in yeast; all share sequence similarity (1). Different yeast histone deacetylase complexes affect transcription of distinct, partially overlapping sets of genes (1, 8).

Last updated: 2000-01-10 Contact SGD

References cited on this page View Complete Literature Guide for HOS1
1) Rundlett SE, et al.  (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8
2) Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8
3) Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
4) Davie JK, et al.  (2003) Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo. J Biol Chem 278(50):50158-62
5) Xiong B, et al.  (2010) Hos1 is a lysine deacetylase for the smc3 subunit of cohesin. Curr Biol 20(18):1660-5
6) Borges V, et al.  (2010) Hos1 deacetylates smc3 to close the cohesin acetylation cycle. Mol Cell 39(5):677-88
7) Mizzen C, et al.  (1998) Signaling to chromatin through histone modifications: how clear is the signal? Cold Spring Harb Symp Quant Biol 63:469-81
8) Suka N, et al.  (1998) The regulation of gene activity by histones and the histone deacetylase RPD3. Cold Spring Harb Symp Quant Biol 63():391-9