Standard Name	HOM6
Systematic Name	YJR139C
Alias	THR6 1
Feature Type	ORF, Verified
Description	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions (2, 3, 4)
Name Description	HOMoserine requiring 2

Chromosomal Location	ChrX:690524 to 689445 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 87 cM

	View Computational GO annotations for HOM6
Molecular Function
Manually curated	homoserine dehydrogenase activity (IDA, ISS)
Biological Process
Manually curated	homoserine biosynthetic process (IMP) methionine biosynthetic process (IMP) threonine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA)

Pathways	homoserine biosynthesis superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Classical genetics
null	tellurium atom accumulation: increased chronological lifespan: increased cold sensitivity: increased gamma ray resistance: decreased heat sensitivity: increased ionic stress resistance: decreased resistance to daunorubicin: decreased resistance to selenium(2+): decreased resistance to tellurite: decreased resistance to ferrozine(2-): decreased resistance to cobalt chloride hexahydrate: decreased resistance to camptothecin: decreased resistance to FK506: decreased resistance to cisplatin: decreased
unspecified	auxotrophy
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased fermentative growth: decreased rate heat sensitivity: increased hyperosmotic stress resistance: decreased ionic stress resistance: decreased oxidative stress resistance: decreased resistance to doxorubicin: decreased resistance to mycophenolic acid: decreased resistance to oxalic acid: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to wortmannin: decreased resistance to sirolimus: decreased resistance to nickel sulfate: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to cadmium dichloride: decreased resistance to hydroxyurea: decreased resistance to acetaldehyde: decreased resistance to propolis extract: decreased resistance to sodium selenide: decreased resistance to acrolein: decreased utilization of nitrogen source: absent vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	371 total interaction(s) for 268 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Co-crystal Structure: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 279 Phenotypic Suppression: 7 Positive Genetic: 55 Synthetic Growth Defect: 10 Synthetic Lethality: 3 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrX:690524 to 689445 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 87 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1080 690524..689445 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003900