HOM6/YJR139C Summary Help

Standard Name HOM6 1
Systematic Name YJR139C
Alias THR6 2
Feature Type ORF, Verified
Description Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions (1, 3, 4)
Name Description HOMoserine requiring 1
Chromosomal Location
ChrX:690524 to 689445 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 87 cM
Gene Ontology Annotations All HOM6 GO evidence and references
  View Computational GO annotations for HOM6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 8 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
374 total interaction(s) for 268 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Co-crystal Structure: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 280
  • Phenotypic Suppression: 7
  • Positive Genetic: 55
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 3
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 359
Molecular Weight (Da) 38,502
Isoelectric Point (pI) 7.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:690524 to 689445 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 87 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1080 690524..689445 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003900
References cited on this page View Complete Literature Guide for HOM6
1) Thomas D, et al.  (1993) Evolutionary relationships between yeast and bacterial homoserine dehydrogenases. FEBS Lett 323(3):289-93
2) Robichon-Szulmajster H, et al.  (1966) Genetic and biochemical studies of genes controlling the synthesis of threonine and methionine in Saccharomyces. Genetics 53(3):609-19
3) Yumoto N, et al.  (1991) Rapid purification and characterization of homoserine dehydrogenase from Saccharomyces cerevisiae. Arch Biochem Biophys 285(2):270-5
4) DeLaBarre B, et al.  (2000) Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nat Struct Biol 7(3):238-44