HOM3/YER052C Summary Help

HOM3 BASIC INFORMATION

Standard Name HOM3 1
Systematic Name YER052C
Alias BOR1 , SIL4
Feature Type ORF, Verified
Description Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis (2, 3, 4, 5)
Name Description HOMoserine requiring 3, 6
GO Annotations All HOM3 GO evidence and references
    View Computational GO annotations for HOM3
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Pathways
Mutant Phenotype All HOM3 Phenotype details and references
Large-scale survey
null
Interactions HOM3 All interactions details and references
51 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 10
  • Reconstituted Complex: 1
  • Two-hybrid: 6
Genetic Interactions
  • Phenotypic Enhancement: 14
  • Phenotypic Suppression: 15
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 3
Sequence Information
ChrV:257957 to 256374 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 48 cM
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1584 257957..256374 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000854

HOM3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HOM3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOM3]

1) Calderon, I.  (1992) Personal Communication, Mortimer Map Edition 11
2) Mountain HA, et al.  (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7(8):781-803
3) Rafalski JA and Falco SC  (1988) Structure of the yeast HOM3 gene which encodes aspartokinase. J Biol Chem 263(5):2146-51
4) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
5) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
6) Rafalski JA and Falco SC  (1990) Structure of the yeast HOM3 gene which encodes aspartokinase. J Biol Chem 265(25):15346