Standard Name	HOM2
Systematic Name	YDR158W
Alias	THR2 1
Feature Type	ORF, Verified
Description	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis (2, 3, 4)
Name Description	HOMoserine requiring 2

Chromosomal Location	ChrIV:770357 to 771454 | ORF Map | GBrowse
	Genetic position: 92 cM

	View Computational GO annotations for HOM2
Molecular Function
Manually curated	aspartate-semialdehyde dehydrogenase activity (IDA)
Biological Process
Manually curated	homoserine biosynthetic process (IMP) methionine biosynthetic process (IMP) threonine biosynthetic process (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA) plasma membrane (IDA)

Pathways	homoserine biosynthesis superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Classical genetics
null	resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased
unspecified	auxotrophy
Large-scale survey
null	acid pH resistance: decreased competitive fitness: decreased resistance to sirolimus: decreased resistance to 1,4-dithiothreitol and tacrolimus (anhydrous): increased resistance to tacrolimus (anhydrous) and tunicamycin: increased resistance to cycloheximide: decreased resistance to wortmannin: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to hydroxyurea: decreased resistance to (S)-lactic acid: decreased resistance to hydrogen chloride: decreased resistance to boric acid: decreased resistance to mycophenolic acid: decreased resistance to doxorubicin: decreased toxin resistance: decreased utilization of nitrogen source: absent viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	158 total interaction(s) for 131 unique genes/features.
Physical Interactions	Affinity Capture-MS: 13 Affinity Capture-RNA: 4 Biochemical Activity: 2 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 97 Phenotypic Enhancement: 7 Phenotypic Suppression: 7 Positive Genetic: 17 Synthetic Growth Defect: 6 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:770357 to 771454 | ORF Map | GBrowse
	Genetic position: 92 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1098 770357..771454 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002565