HOM2/YDR158W Summary

HOM2 BASIC INFORMATION

Standard Name	HOM2
Systematic Name	YDR158W
Feature Type	ORF, Verified
Description	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis (1, 2, 3)
Name Description	HOMoserine requiring 1

GO Annotations	All HOM2 GO evidence and references
	View Computational GO annotations for HOM2
Molecular Function
Manually curated	aspartate-semialdehyde dehydrogenase activity (TAS)
Biological Process
Manually curated	homoserine biosynthetic process (TAS) methionine metabolic process (TAS) threonine metabolic process (TAS)
High-throughput	response to drug (IMP)
Cellular Component
High-throughput	cytoplasm (IDA) nucleus (IDA) plasma membrane enriched fraction (IDA)

Pathways	homoserine biosynthesis superpathway of methionine biosynthesis superpathway of sulfur amino acid biosynthesis superpathway of threonine and methionine biosynthesis superpathway of threonine biosynthesis threonine biosynthesis

Mutant Phenotype	All HOM2 Phenotype details and references
Classical genetics
null	resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased
Large-scale survey
null	competitive fitness: decreased resistance to rapamycin: decreased resistance to wortmannin: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to mycophenolic acid: decreased resistance to hydroxyurea: decreased resistance to doxorubicin: decreased toxin resistance: decreased viable

Interactions	HOM2 All interactions details and references
	20 total interaction(s) for 20 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 2 Biochemical Activity: 2
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 2 Synthetic Rescue: 4

Sequence Information

ChrIV:770355 to 771452 | |

Genetic position: 92 cM

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1098	770355..771452	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002565

HOM2 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for HOM2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOM2]

1)	Thomas D and Surdin-Kerjan Y (1989) Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression. Mol Gen Genet 217(1):149-54
2)	Mountain HA, et al. (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7(8):781-803
3)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press

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