HOM2/YDR158W Summary Help

Standard Name HOM2 1
Systematic Name YDR158W
Alias THR2 2
Feature Type ORF, Verified
Description Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis (1, 3, 4)
Name Description HOMoserine requiring 1
Chromosomal Location
ChrIV:770357 to 771454 | ORF Map | GBrowse
Gbrowse
Genetic position: 92 cM
Gene Ontology Annotations All HOM2 GO evidence and references
  View Computational GO annotations for HOM2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 13 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
Resources
161 total interaction(s) for 132 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 4
  • Biochemical Activity: 2
  • PCA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 97
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 7
  • Positive Genetic: 17
  • Synthetic Growth Defect: 6
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 365
Molecular Weight (Da) 39,543
Isoelectric Point (pI) 6.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:770357 to 771454 | ORF Map | GBrowse
SGD ORF map
Genetic position: 92 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1098 770357..771454 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002565
References cited on this page View Complete Literature Guide for HOM2
1) Thomas D and Surdin-Kerjan Y  (1989) Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression. Mol Gen Genet 217(1):149-54
2) Robichon-Szulmajster H, et al.  (1966) Genetic and biochemical studies of genes controlling the synthesis of threonine and methionine in Saccharomyces. Genetics 53(3):609-19
3) Mountain HA, et al.  (1991) Four major transcriptional responses in the methionine/threonine biosynthetic pathway of Saccharomyces cerevisiae. Yeast 7(8):781-803
4) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press