Standard Name	HMO1 1
Systematic Name	YDR174W
Alias	HSM2
Feature Type	ORF, Verified
Description	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase (1, 2, 3, 4)
Name Description	High MObility group (HMG) family 1

Chromosomal Location	ChrIV:812110 to 812850 | ORF Map | GBrowse

	View Computational GO annotations for HMO1
Molecular Function
Manually curated	DNA binding, bending (IDA) double-stranded DNA binding (IDA) four-way junction DNA binding (IDA)
Biological Process
Manually curated	regulation of ribosomal protein gene transcription from RNA polymerase II promoter (IGI, IMP) regulation of transcription by chromatin organization (IDA) regulation of transcription from RNA polymerase I promoter (IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) colocalizes_with nuclear chromatin (IDA) nucleolus (IDA)

Resources	YeTFaSCo

Classical genetics
null	tellurium atom accumulation: increased chromosome/plasmid maintenance: abnormal cold sensitivity: increased mutation frequency: increased oxidative stress resistance: decreased resistance to cisplatin: decreased resistance to tellurite: decreased vegetative growth: decreased rate vegetative growth: decreased
Large-scale survey
null	auxotrophy bud morphology: abnormal budding pattern: abnormal cell cycle progression in G1 phase: increased duration cell cycle progression in G1 phase: delayed competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate freeze-thaw resistance: decreased haploinsufficient heat sensitivity: increased lipid particle morphology: abnormal resistance to caffeine: decreased resistance to hygromycin B: decreased resistance to doxorubicin: decreased resistance to sorbate: decreased stress resistance: increased telomere length: increased toxin resistance: increased transposable element transposition: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	364 total interaction(s) for 281 unique genes/features.
Physical Interactions	Affinity Capture-MS: 91 Affinity Capture-RNA: 4 Affinity Capture-Western: 5 Co-purification: 1 PCA: 1 Two-hybrid: 11
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Negative Genetic: 166 Phenotypic Enhancement: 6 Phenotypic Suppression: 1 Positive Genetic: 14 Synthetic Growth Defect: 39 Synthetic Lethality: 16 Synthetic Rescue: 7
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:812110 to 812850 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..741 812110..812850 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002581