HKR1/YDR420W Summary Help

Standard Name HKR1 1
Systematic Name YDR420W
Feature Type ORF, Verified
Description Mucin family member that functions as an osmosensor in the HOG pathway; functions in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection (2, 3, 4)
Name Description Hansenula mrakii Killer toxin Resistant 1
Chromosomal Location
ChrIV:1306267 to 1311675 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HKR1 GO evidence and references
  View Computational GO annotations for HKR1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
overexpression
reduction of function
Large-scale survey
null
Resources
84 total interaction(s) for 73 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • PCA: 1
  • Protein-RNA: 1
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 44
  • Positive Genetic: 4
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 12
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,802
Molecular Weight (Da) 188,945
Isoelectric Point (pI) 4.54
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1306267 to 1311675 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..5409 1306267..1311675 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002828
References cited on this page View Complete Literature Guide for HKR1
1) Kasahara S, et al.  (1994) Cloning of the Saccharomyces cerevisiae gene whose overexpression overcomes the effects of HM-1 killer toxin, which inhibits beta-glucan synthesis. J Bacteriol 176(5):1488-99
2) Yabe T, et al.  (1996) HKR1 encodes a cell surface protein that regulates both cell wall beta-glucan synthesis and budding pattern in the yeast Saccharomyces cerevisiae. J Bacteriol 178(2):477-83
3) Tatebayashi K, et al.  (2007) Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway. EMBO J 26(15):3521-33
4) Pitoniak A, et al.  (2009) The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response. Mol Biol Cell 20(13):3101-14