HIS7/YBR248C Summary Help

HIS7 BASIC INFORMATION

Standard Name HIS7 1, 2
Systematic Name YBR248C
Feature Type ORF, Verified
Description Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor (1, 3, 4 and see Summary Paragraph)
Name Description HIStidine requiring 1
GO Annotations All HIS7 GO evidence and references
    View Computational GO annotations for HIS7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Pathways
Mutant Phenotype All HIS7 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions HIS7 All interactions details and references
6 total interaction(s) for 6 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
Genetic Interactions
  • Dosage Lethality: 1
  • Synthetic Growth Defect: 3
Sequence Information
ChrII:716460 to 714802 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 146 cM
Last Update Coordinates: 2004-07-16 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1659 716460..714802 2004-07-16 1997-01-28
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000452

HIS7 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HIS7

SUMMARY PARAGRAPH for HIS7

HIS7 encodes imidazoleglycerol-phosphate synthase, also called glutamine amidotransferase:cyclase, which catalyzes the fifth step in histidine biosynthesis (5, 4). The biosynthesis of histidine has been most extensively studied in Salmonella typhimurium and E. coli. The reactions and enzymes involved in histidine biosynthesis have been identified in many organisms, and are thoroughly reviewed in Alifano et al. (4). Mutations in HIS7, as well as in genes encoding other histidine biosynthetic enzymes, cause histidine auxotrophy and sensitivity to copper, cobalt, and nickel salts (6). The transcription factors Bas1p and Pho2p activate HIS7 transcription (7).

Last updated: 1999-11-12

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HIS7]

1) Kuenzler M, et al.  (1993) Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae. J Bacteriol 175(17):5548-58
2) Plotkin, D.J.  (1978) Commitment to meiotic recombination: a temporal analysis. Ph.D Thesis
3) Chittur SV, et al.  (2000) Expression and purification of imidazole glycerol phosphate synthase from Saccharomyces cerevisiae. Protein Expr Purif 18(3):366-77
4) Alifano P, et al.  (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69
5) Fani R, et al.  (1997) Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Gene 197(1-2):9-17
6) Pearce DA and Sherman F  (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
7) Springer C, et al.  (1996) Amino acid and adenine cross-pathway regulation act through the same 5'-TGACTC-3' motif in the yeast HIS7 promoter. J Biol Chem 271(47):29637-43