HIS6/YIL020C Summary Help

HIS6 BASIC INFORMATION

Standard Name HIS6 1
Systematic Name YIL020C
Feature Type ORF, Verified
Description Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts (1, 2, 3 and see Summary Paragraph)
Name Description HIStidine requiring 1
GO Annotations All HIS6 GO evidence and references
    View Computational GO annotations for HIS6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Pathways
Mutant Phenotype All HIS6 Phenotype details and references
Classical genetics
unspecified
Large-scale survey
null
Interactions HIS6 All interactions details and references
5 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
Genetic Interactions
  • Synthetic Rescue: 1
Sequence Information
ChrIX:314818 to 314033 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -17 cM
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..786 314818..314033 1994-12-10 1994-12-10
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001282

HIS6 RESOURCES

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Expression Summary histogram

ADDITIONAL INFORMATION for HIS6

SUMMARY PARAGRAPH for HIS6

HIS6 encodes N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazole carboxamide isomerase, which catalyzes the fourth step in histidine biosynthesis (1, 3). The biosynthesis of histidine has been most extensively studied in Salmonella typhimurium and E. coli. The reactions and enzymes involved in histidine biosynthesis have been identified in many organisms, and are thoroughly reviewed in Alifano et al. (3). Mutations in HIS6, as well as in genes encoding other histidine biosynthetic enzymes, cause histidine auxotrophy and sensitivity to copper, cobalt, and nickel salts (2).

Last updated: 1999-11-12

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HIS6]

1) Fani R, et al.  (1997) Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Gene 197(1-2):9-17
2) Pearce DA and Sherman F  (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
3) Alifano P, et al.  (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69