HIS6/YIL020C Summary Help

Standard Name HIS6 1
Systematic Name YIL020C
Feature Type ORF, Verified
Description Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts (1, 2, 3 and see Summary Paragraph)
Name Description HIStidine requiring 1
Chromosomal Location
ChrIX:314820 to 314035 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -17 cM
Gene Ontology Annotations All HIS6 GO evidence and references
  View Computational GO annotations for HIS6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 4 genes
Resources
Pathways
Classical genetics
unspecified
Large-scale survey
null
Resources
16 total interaction(s) for 16 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1

Genetic Interactions
  • Negative Genetic: 2
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 261
Molecular Weight (Da) 29,556
Isoelectric Point (pI) 5.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:314820 to 314035 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -17 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..786 314820..314035 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001282
SUMMARY PARAGRAPH for HIS6

HIS6 encodes N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazole carboxamide isomerase, which catalyzes the fourth step in histidine biosynthesis (1, 3). The biosynthesis of histidine has been most extensively studied in Salmonella typhimurium and E. coli. The reactions and enzymes involved in histidine biosynthesis have been identified in many organisms, and are thoroughly reviewed in Alifano et al. (3). Mutations in HIS6, as well as in genes encoding other histidine biosynthetic enzymes, cause histidine auxotrophy and sensitivity to copper, cobalt, and nickel salts (2).

Last updated: 1999-11-12 Contact SGD

References cited on this page View Complete Literature Guide for HIS6
1) Fani R, et al.  (1997) Paralogous histidine biosynthetic genes: evolutionary analysis of the Saccharomyces cerevisiae HIS6 and HIS7 genes. Gene 197(1-2):9-17
2) Pearce DA and Sherman F  (1999) Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. J Bacteriol 181(16):4774-9
3) Alifano P, et al.  (1996) Histidine biosynthetic pathway and genes: structure, regulation, and evolution. Microbiol Rev 60(1):44-69