HIR3/YJR140C Summary Help

Standard Name HIR3 1
Systematic Name YJR140C
Alias HPC1
Feature Type ORF, Verified
Description Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein (1, 2, 3, 4, 5, 6, 7)
Name Description HIstone Regulation 2
Chromosomal Location
ChrX:695696 to 690750 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All HIR3 GO evidence and references
  View Computational GO annotations for HIR3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 9 genes
Regulators 5 genes
Classical genetics
Large-scale survey
258 total interaction(s) for 157 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-Western: 3
  • Co-purification: 1
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 188
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 2
  • Positive Genetic: 14
  • Synthetic Growth Defect: 16
  • Synthetic Lethality: 5

Expression Summary
Length (a.a.) 1,648
Molecular Weight (Da) 191,678
Isoelectric Point (pI) 6.16
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrX:695696 to 690750 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
This feature contains embedded feature(s): YJR140W-A
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..4947 695696..690750 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003901
References cited on this page View Complete Literature Guide for HIR3
1) Xu H, et al.  (1992) Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae. Mol Cell Biol 12(11):5249-59
2) Osley MA and Lycan D  (1987) Trans-acting regulatory mutations that alter transcription of Saccharomyces cerevisiae histone genes. Mol Cell Biol 7(12):4204-10
3) Qian Z, et al.  (1998) Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins. Mol Cell Biol 18(8):4783-92
4) Spector MS, et al.  (1997) Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol 17(2):545-52
5) Formosa T, et al.  (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71
6) Prochasson P, et al.  (2005) The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF. Genes Dev 19(21):2534-9
7) Rai TS, et al.  (2011) Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex. Mol Cell Biol 31(19):4107-18