Standard Name	HIP1 1
Systematic Name	YGR191W
Feature Type	ORF, Verified
Description	High-affinity histidine permease, also involved in the transport of manganese ions (1, 2)
Name Description	HIstidine Permease 1

Chromosomal Location	ChrVII:880420 to 882231 | ORF Map | GBrowse
	Genetic position: 146 cM

	View Computational GO annotations for HIP1
Molecular Function
Manually curated	high affinity L-histidine transmembrane transporter activity (IMP)
Biological Process
Manually curated	histidine transport (IMP) manganese ion transport (IMP)
Cellular Component
Manually curated	plasma membrane (IMP, ISS)
High-throughput	integral to membrane (ISM)

Classical genetics
null	copper(2+) accumulation: decreased nickel(2+) accumulation: decreased zinc(2+) accumulation: decreased cobalt(2+) accumulation: decreased cold sensitivity: increased resistance to nelfinavir: decreased resistance to cobalt(2+): decreased resistance to nickel(2+): decreased resistance to copper(2+): decreased resistance to zinc(2+): decreased vegetative growth: decreased
unspecified	manganese(2+) accumulation: decreased nutrient uptake: decreased resistance to hydrogen peroxide: decreased resistance to manganese(2+): increased vegetative growth: decreased rate vegetative growth: absent
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased
reduction of function	competitive fitness: decreased resistance to tunicamycin: decreased resistance to benomyl: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	29 total interaction(s) for 19 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Co-purification: 1 PCA: 11
Genetic Interactions	Dosage Growth Defect: 2 Negative Genetic: 8 Phenotypic Enhancement: 1 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:880420 to 882231 | ORF Map | GBrowse
	Genetic position: 146 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1812 880420..882231 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000003423