HFD1/YMR110C Summary Help

Standard Name HFD1 1
Systematic Name YMR110C
Feature Type ORF, Verified
Description Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder (1, 2)
Name Description Homolog of Fatty aldehyde Dehydrogenase 1
Chromosomal Location
ChrXIII:491992 to 490394 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HFD1 GO evidence and references
  View Computational GO annotations for HFD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Classical genetics
null
Large-scale survey
null
Resources
38 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Co-fractionation: 1
  • PCA: 3
  • Protein-peptide: 2
  • Reconstituted Complex: 1

Genetic Interactions
  • Negative Genetic: 16
  • Positive Genetic: 9
  • Synthetic Growth Defect: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 532
Molecular Weight (Da) 59,978
Isoelectric Point (pI) 6.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:491992 to 490394 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1599 491992..490394 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004716
References cited on this page View Complete Literature Guide for HFD1
1) Zahedi RP, et al.  (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17(3):1436-50
2) Nakahara K, et al.  (2012) The sjogren-larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell 46(4):461-71