HFA1/YMR207C Summary

HFA1 BASIC INFORMATION

Standard Name	HFA1
Systematic Name	YMR207C
Feature Type	ORF, Verified
Description	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis (1, 2, 3)

GO Annotations	All HFA1 GO evidence and references
	View Computational GO annotations for HFA1
Molecular Function
Manually curated	acetyl-CoA carboxylase activity (IGI, ISS)
Biological Process
Manually curated	fatty acid biosynthetic process (IGI)
Cellular Component
Manually curated	mitochondrion (IDA)
High-throughput	mitochondrion (IDA)

Pathways	fatty acid biosynthesis, initial steps

Mutant Phenotype	All HFA1 Phenotype details and references
Large-scale survey
null	glycogen accumulation: decreased resistance to citric acid: decreased respiratory growth: decreased rate viable

Interactions	HFA1 All interactions details and references
	12 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 1 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Synthetic Growth Defect: 1

Sequence Information

ChrXIII:683563 to 677192 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..6372	683563..677192	1996-07-31	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004820

HFA1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HFA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HFA1]

1)	Kearsey SE (1993) Identification of a Saccharomyces cerevisiae gene closely related to FAS3 (acetyl-CoA carboxylase) DNA Seq 4(1):69-70
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Hoja U, et al. (2004) HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae. J Biol Chem 279(21):21779-86

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