Standard Name	SLX5 1
Systematic Name	YDL013W
Alias	HEX3 2 , ULS2 3
Feature Type	ORF, Verified
Description	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers (1, 4, 5, 6, 7)
Name Description	Synthetic Lethal of unknown [X] function 1

Chromosomal Location	ChrIV:429067 to 430926 | ORF Map | GBrowse
	Genetic position: -1.69 cM

	View Computational GO annotations for SLX5
Molecular Function
Manually curated	SUMO binding (IDA, IPI) contributes_to ubiquitin-protein ligase activity (IDA)
Biological Process
Manually curated	protein sumoylation (IGI, IMP) protein ubiquitination (IDA) response to DNA damage stimulus (IGI, IMP) telomere maintenance (IMP)
Cellular Component
Manually curated	nucleus (IDA) ubiquitin ligase complex (IDA)

Classical genetics
null	UV resistance: decreased tellurium atom accumulation: increased chromosome/plasmid maintenance: abnormal Matalpha1p accumulation: increased Sumoylated-Mot1p accumulation: increased Spt20p accumulation: increased resistance to tellurite: decreased resistance to canavanine: decreased resistance to hydroxyurea: decreased
reduction of function	resistance to hydroxyurea: decreased
Large-scale survey
null	UV resistance: decreased cell cycle progression in G1 phase: decreased duration competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate haploproficient heat sensitivity: increased resistance to hydroxyurea: decreased resistance to cisplatin: decreased resistance to methyl methanesulfonate: decreased resistance to sodium arsenite: decreased resistance to doxorubicin: decreased resistance to hygromycin B: decreased resistance to cycloheximide: decreased sporulation: decreased toxin resistance: decreased vacuolar morphology: abnormal viable
overexpression	inviable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	641 total interaction(s) for 418 unique genes/features.
Physical Interactions	Affinity Capture-MS: 12 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 14 Co-purification: 1 Reconstituted Complex: 5 Two-hybrid: 34
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 3 Negative Genetic: 275 Phenotypic Enhancement: 5 Phenotypic Suppression: 3 Positive Genetic: 85 Synthetic Growth Defect: 127 Synthetic Lethality: 57 Synthetic Rescue: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:429067 to 430926 | ORF Map | GBrowse
	Genetic position: -1.69 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1860 429067..430926 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002171