HES1/YOR237W Summary Help

Standard Name HES1 1
Systematic Name YOR237W
Alias OSH5 2
Feature Type ORF, Verified
Description Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); HES1 has a paralog, KES1, that arose from the whole genome duplication (1, 2, 3)
Name Description Homologous to kES1 1
Chromosomal Location
ChrXV:781994 to 783298 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HES1 GO evidence and references
  View Computational GO annotations for HES1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
30 total interaction(s) for 23 unique genes/features.
Physical Interactions
  • Co-purification: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Negative Genetic: 23
  • Phenotypic Enhancement: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 434
Molecular Weight (Da) 49,505
Isoelectric Point (pI) 7.22
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:781994 to 783298 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1305 781994..783298 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005763
References cited on this page View Complete Literature Guide for HES1
1) Jiang B, et al.  (1994) A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Yeast 10(3):341-53
2) Beh CT, et al.  (2001) Overlapping functions of the yeast oxysterol-binding protein homologues. Genetics 157(3):1117-40
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61