HER1/YOR227W Summary Help

Standard Name HER1 1
Systematic Name YOR227W
Feature Type ORF, Verified
Description Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication (1, 2, 3)
Name Description Hmg2p ER Remodeling 1
Chromosomal Location
ChrXV:762825 to 766565 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HER1 GO evidence and references
  View Computational GO annotations for HER1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
25 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 3
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 4
  • Positive Genetic: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,246
Molecular Weight (Da) 139,456
Isoelectric Point (pI) 9.6
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:762825 to 766565 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3741 762825..766565 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005753
References cited on this page View Complete Literature Guide for HER1
1) Federovitch CM, et al.  (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Fleischer TC, et al.  (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307