HEM15/YOR176W Summary

HEM15 BASIC INFORMATION

Standard Name	HEM15 1
Systematic Name	YOR176W
Feature Type	ORF, Verified
Description	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway (1, 2, 3)
Name Description	HEMe biosynthesis 1

GO Annotations	All HEM15 GO evidence and references
	View Computational GO annotations for HEM15
Molecular Function
Manually curated	ferrochelatase activity (IDA, IMP)
Biological Process
Manually curated	heme biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Pathways	heme biosynthesis superpathway of heme and siroheme biosynthesis

Mutant Phenotype	All HEM15 Phenotype details and references
Classical genetics
null	resistance to sampangine: decreased
unspecified	heme accumulation: absent utilization of carbon source: absent
Large-scale survey
null	inviable

Interactions	HEM15 All interactions details and references
	12 total interaction(s) for 10 unique genes/features.
Physical Interactions	Affinity Capture-MS: 8 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Co-crystal Structure: 1 Reconstituted Complex: 1

Sequence Information

ChrXV:662402 to 663583 | |

Last Update

Coordinates: 2006-01-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1182	662402..663583	2006-01-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005702

HEM15 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HEM15

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HEM15]

1)	Urban-Grimal D and Labbe-Bois R (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92
2)	Labbe-Bois R (1990) The ferrochelatase from Saccharomyces cerevisiae. Sequence, disruption, and expression of its structural gene HEM15. J Biol Chem 265(13):7278-83
3)	Camadro JM and Labbe P (1988) Purification and properties of ferrochelatase from the yeast Saccharomyces cerevisiae. Evidence for a precursor form of the protein. J Biol Chem 263(24):11675-82

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