HEM15/YOR176W Summary Help

Standard Name HEM15 1
Systematic Name YOR176W
Feature Type ORF, Verified
Description Ferrochelatase; a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway (1, 2, 3)
Name Description HEMe biosynthesis 1
Chromosomal Location
ChrXV:662401 to 663582 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HEM15 GO evidence and references
  View Computational GO annotations for HEM15
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
null
reduction of function
Resources
24 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 5
  • Co-crystal Structure: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 1

Genetic Interactions
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 44,596
Isoelectric Point (pI) 9.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:662401 to 663582 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 662401..663582 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005702
References cited on this page View Complete Literature Guide for HEM15
1) Urban-Grimal D and Labbe-Bois R  (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92
2) Labbe-Bois R  (1990) The ferrochelatase from Saccharomyces cerevisiae. Sequence, disruption, and expression of its structural gene HEM15. J Biol Chem 265(13):7278-83
3) Camadro JM and Labbe P  (1988) Purification and properties of ferrochelatase from the yeast Saccharomyces cerevisiae. Evidence for a precursor form of the protein. J Biol Chem 263(24):11675-82