Standard Name	HEM14 1
Systematic Name	YER014W
Feature Type	ORF, Verified
Description	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides (1, 2, 3)
Name Description	HEMe biosynthesis 1

Chromosomal Location	ChrV:182600 to 184219 | ORF Map | GBrowse

	View Computational GO annotations for HEM14
Molecular Function
Manually curated	oxygen-dependent protoporphyrinogen oxidase activity (IDA, IMP)
Biological Process
Manually curated	heme biosynthetic process (IMP)
Cellular Component
Manually curated	mitochondrial inner membrane (IDA)
High-throughput	mitochondrion (IDA)

Pathways	heme biosynthesis superpathway of heme and siroheme biosynthesis

Classical genetics
null	resistance to sampangine: decreased
unspecified	heme accumulation: absent utilization of carbon source: absent
Large-scale survey
null	budding pattern: abnormal cell shape: abnormal competitive fitness: decreased haploinsufficient heat sensitivity: increased lipid particle morphology: abnormal resistance to doxorubicin: decreased resistance to sulfanilamide: decreased resistance to sodium arsenite: decreased respiratory growth: absent respiratory growth: decreased rate starvation resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	32 total interaction(s) for 32 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 2 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 2 Synthetic Growth Defect: 16 Synthetic Lethality: 6
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:182600 to 184219 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1620 182600..184219 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000816