HEM13/YDR044W Summary Help

Standard Name HEM13 1
Systematic Name YDR044W
Feature Type ORF, Verified
Description Coproporphyrinogen III oxidase; an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) (1, 2, 3, 4)
Name Description HEMe biosynthesis 1
Chromosomal Location
ChrIV:546642 to 547628 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HEM13 GO evidence and references
  View Computational GO annotations for HEM13
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 12 genes
Resources
Pathways
Classical genetics
null
unspecified
Large-scale survey
conditional
null
reduction of function
Resources
49 total interaction(s) for 47 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 17
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • Protein-peptide: 4
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 21
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 328
Molecular Weight (Da) 37,711
Isoelectric Point (pI) 6.8
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:546642 to 547628 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..987 546642..547628 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002451
References cited on this page View Complete Literature Guide for HEM13
1) Urban-Grimal D and Labbe-Bois R  (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92
2) Amillet JM, et al.  (1995) Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae. Curr Genet 28(6):503-11
3) Keng T  (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23
4) Zagorec M, et al.  (1988) Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J Biol Chem 263(20):9718-24