HEK2/YBL032W Summary Help

Standard Name HEK2 1
Systematic Name YBL032W
Alias KHD1 2
Feature Type ORF, Verified
Description RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K (1, 2, 3)
Name Description HEterogeneous nuclear rnp K-like gene 1
Chromosomal Location
ChrII:160184 to 161329 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All HEK2 GO evidence and references
  View Computational GO annotations for HEK2
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 14 genes
Resources
Classical genetics
activation
null
overexpression
Large-scale survey
null
overexpression
Resources
1189 total interaction(s) for 1151 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 50
  • Affinity Capture-RNA: 1091
  • Biochemical Activity: 4
  • Protein-RNA: 4
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 5
  • Negative Genetic: 4
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 4
  • Positive Genetic: 5
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 381
Molecular Weight (Da) 41,683
Isoelectric Point (pI) 5.97
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrII:160184 to 161329 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1146 160184..161329 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000128
References cited on this page View Complete Literature Guide for HEK2
1) Denisenko O and Bomsztyk K  (2002) Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length. Mol Cell Biol 22(1):286-97
2) Irie K, et al.  (2002) The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J 21(5):1158-67
3) Paquin N, et al.  (2007) Local Activation of Yeast ASH1 mRNA Translation through Phosphorylation of Khd1p by the Casein Kinase Yck1p. Mol Cell 26(6):795-809