HEH2/YDR458C Summary Help

Standard Name HEH2 1
Systematic Name YDR458C
Feature Type ORF, Verified
Description Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication (1, 2, 3)
Name Description Helix-Extension-Helix domain 1
Chromosomal Location
ChrIV:1382046 to 1380055 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All HEH2 GO evidence and references
  View Computational GO annotations for HEH2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Large-scale survey
null
overexpression
unspecified
Resources
30 total interaction(s) for 24 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 2
  • Affinity Capture-Western: 3
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 5
  • Positive Genetic: 1
  • Synthetic Growth Defect: 8
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 663
Molecular Weight (Da) 76,376
Isoelectric Point (pI) 7.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1382046 to 1380055 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1992 1382046..1380055 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002866
References cited on this page View Complete Literature Guide for HEH2
1) King MC, et al.  (2006) Karyopherin-mediated import of integral inner nuclear membrane proteins. Nature 442(7106):1003-7
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61